Pre-treatment with puerarin affects pharmacokinetics of warfarin, but not clopidogrel, in experimental rats / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 257-263, 2015.
Article
in English
| WPRIM
| ID: wpr-812149
ABSTRACT
The present study was designed to determine the effects of puerarin pre-treatment on the pharmacokinetics of the oral anticoagulant agent warfarin and the antiplatelet agent clopidogrel in rats. In the treatment group, rats was gavaged with warfarin or clopidogrel after repeated treatment with puerarin at intraperitoneal doses of 20, 60, or 200 mg·kg(-1) for 7 days, while rats in the control group were administrated only with the same dose warfarin or clopidogrel. Plasma samples were obtained at the prescribed times and analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS). The results showed that rats treated with puerarin at all the test doses of 20, 60 and 200 mg·kg(-1) were found to affect the pharmacokinetics of warfarin, but not clopidogrel, suggesting a potential herb-drug interaction between puerarin and warfarin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Vasodilator Agents
/
Warfarin
/
Ticlopidine
/
Drug Administration Schedule
/
Pharmacokinetics
/
Platelet Aggregation Inhibitors
/
Chromatography, Liquid
/
Rats, Wistar
/
Herb-Drug Interactions
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2015
Type:
Article
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