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Quercetin-3-O-β-D-glucopyranosyl-(4→1)-α-L-rhamnoside metabolites in the rat using UPLC-Q-TOF/MS / 中国天然药物
Article in English | WPRIM | ID: wpr-812210
Responsible library: WPRO
ABSTRACT
Ultraperformance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) and the Metabolynx™ software, combined with mass defect filtering, were applied to identity the metabolites of quercetin-3-O-β-D-gluco-pyranosyl-(4→1)-α-L-rhamnoside (QGR) in rats after intravenous administration. MS(E) was used for simultaneous acquisition of precursor ion information and fragment ion data at high and low collision energy in one analytical run, which facilitated the rapid structural characterization of eight metabolites in rat plasma, urine and bile. The results indicated that methylation and glucuronidation were the major metabolic pathways of QGR in vivo. The present study provided important information about the metabolism of QGR which will be useful for fully understanding the mechanism of action of this compound. Furthermore, this work demonstrated the potential of the UPLC-Q-TOF/MS approach using Metabolynx for rapid and automated research of the metabolites of natural products.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quercetin / Mass Spectrometry / Male / Plant Extracts / Chemistry / Chromatography, High Pressure Liquid / Rats, Sprague-Dawley / Ginkgo biloba / Administration, Intravenous / Animals Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quercetin / Mass Spectrometry / Male / Plant Extracts / Chemistry / Chromatography, High Pressure Liquid / Rats, Sprague-Dawley / Ginkgo biloba / Administration, Intravenous / Animals Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2014 Type: Article