Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureu / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 685-688, 2014.
Article
in English
| WPRIM
| ID: wpr-812215
ABSTRACT
AIM@#To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill.@*METHOD@#Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compounds were identified by comparison of their data with those reported.@*RESULTS@#Three mycophenolic acid derivatives, 6-((2E, 6E)-3, 7-dimethyldeca-2, 6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one (1), 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-5, 7-dihydroxy-4-methylphtanlan-1-one (2), and 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one (3) were isolated.@*CONCLUSION@#Among them, compound 1 was new, and compound 2 exhibited moderate cytotoxicity against HL-60, SMMC-7721, A-549, and MCF-7 cells, with IC50 values of 39.1, 31.1, 27.4, and 35.7 μmol·L(-1), respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phenols
/
Biological Products
/
Molecular Structure
/
Chemistry
/
HL-60 Cells
/
Polyporales
/
Agaricales
/
Therapeutic Uses
/
Drug Therapy
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2014
Type:
Article
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