A new bufadienolide with cytotoxic activity from the Chinese traditional drug Ch'an Su / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 623-627, 2014.
Article
in English
| WPRIM
| ID: wpr-812224
ABSTRACT
AIM@#To study the bufadienolides in the Chinese traditional drug "Ch'an Su" and their cytotoxic activity.@*METHOD@#Various chromatographic techniques were used to isolate the constituents, and their structures were elucidated through physical and spectroscopic data.@*RESULTS@#Twenty compounds were isolated, and eighteen were evaluated in vitro for their cytotoxic activity against A-549 and K-562 cells.@*CONCLUSION@#Compound 1 (bufalin 3β-acrylic ester) was a new bufadienolide and exhibited the most potent activity against the two tumor cell lines with IC50 values of 7.16 and 6.83 nmol · L(-1). The relationships between structure and activity are discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Structure-Activity Relationship
/
Biological Products
/
Bufanolides
/
Molecular Structure
/
Chemistry
/
K562 Cells
/
Inhibitory Concentration 50
/
Therapeutic Uses
/
Drug Therapy
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2014
Type:
Article
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