Protective effect of Nigella sativa oil against binge ethanol-induced oxidative stress and liver injury in rats / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 495-499, 2014.
Article
in English
| WPRIM
| ID: wpr-812242
ABSTRACT
AIM@#Nigella sativa L. (Ranunculaceae) is considered as a therapeutic plant-based medicine for liver damage. In this study, the aim was to study the effect of Nigella sativa oil (NSO) pretreatment on ethanol-induced hepatotoxicity in rats.@*METHOD@#Rats were given Nigella sativa oil at doses of 2.5 and 5.0 mL·kg(-1), orally for 3 weeks, followed by oral ethanol (EtOH) administration (5 g·kg(-1)) every 12 h three times (binge model).@*RESULTS@#Binge ethanol application caused significant increases in plasma transaminase activities and hepatic triglyceride and malondialdehyde (MDA) levels. It decreased hepatic glutathione (GSH) levels, but did not change vitamins E and vitamin C levels and antioxidant enzyme activities. NSO (5.0 mL·kg(-1)) pretreatment significantly decreased plasma transaminase activities, hepatic MDA, and triglyceride levels together with amelioration in hepatic histopathological findings.@*CONCLUSION@#NSO pretreatment may be effective in protecting oxidative stress-induced hepatotoxicity after ethanol administration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Superoxide Dismutase
/
Wounds and Injuries
/
Blood
/
Plant Oils
/
Chemistry
/
Nigella sativa
/
Rats, Sprague-Dawley
/
Oxidative Stress
/
Protective Agents
/
Disease Models, Animal
Type of study:
Prognostic study
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2014
Type:
Article
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