Mixed nanomicelles loaded with thymopeptides-sodium deoxycholate/phospholipid improve drug absorption / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 65-70, 2014.
Article
in English
| WPRIM
| ID: wpr-812307
ABSTRACT
AIM@#To improve the absorption of thymopeptides (TH) by preparing sodium deoxycholate/phospholipid-mixed nanomicelles (SDC/PL-MMs).@*METHODS@#TH-SDC/PL-MMs were prepared by a film dispersion method, and then evaluated using photon correlation spectroscopy (PCS), zeta potential measurement, as well as their physical stability after storage for several days. Furthermore, in situ intestinal single-pass perfusion experiments and pharmacodynamics in immunodeficient mice were performed to make a comparison with TH powders and the control drug in absorption properties.@*RESULTS@#A narrow size distribution of nanomicelles, with a mean particle size of (149 ± 8.32) nm and a zeta potential of (-31.05 ± 2.52) mV, was obtained. The in situ intestine perfusion experiments demonstrated a significant advantage in absorption characteristics for TH compared to the other formulations, and oral administration of TH-SDC/PL-MMs potentiated an equivalent effect with i.h. TH in pharmacodynamic studies in immunodeficient mice.@*CONCLUSIONS@#TH-SDC/PL-MMs prepared by a film dispersion method are able to improve the absorption of TH. SDC/PL-MMs might be a good approach for the more effective delivery of drugs like TH.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Peptides
/
Phospholipids
/
Thymus Gland
/
Drug Carriers
/
Pharmacokinetics
/
Chemistry
/
Chemistry, Pharmaceutical
/
Rats, Wistar
/
Deoxycholic Acid
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2014
Type:
Article
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