Chemical constituents of Euphorbia tibetica and their biological activities / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 38-42, 2014.
Article
in English
| WPRIM
| ID: wpr-812311
ABSTRACT
AIM@#To investigate the chemical constituents and their biological activities of the aerial parts of Euphorbia tibetica.@*METHOD@#Compounds were isolated and purified by various chromatographic methods, and their structures were elucidated through the use of extensive spectroscopic techniques including 2D-NMR, the structures of compounds 5 and 6 were confirmed by single-crystal X-ray crystallography. Bioactivities of all the isolated compounds were evaluated by the MTT method on A549 and anti-angiogenesis assay.@*RESULTS@#One new compound, methyl 4-epi-shikimate-3-O-gallate (1), together with twenty-three known constituents (2-24) were isolated from the aerial parts of E. tibetica.@*CONCLUSION@#Compound 1 is new, and the other compounds were isolated from this plant for the first time. Compounds 5-7, 9, 11, 17, 18 and 20 exhibited inhibitory effects on the growth of human lung cancer cell A549 and compounds 5, 7, 12, 13, 17 and 19 showed anti-angiogenic effects in a zebrafish model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Zebrafish
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Cell Line
/
Chemistry
/
Angiogenesis Inhibitors
/
Euphorbia
/
Cell Proliferation
/
Growth Inhibitors
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2014
Type:
Article
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