The identification and pharmacokinetic studies of metabolites of salvianolic acid B after intravenous administration in rats / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 560-565, 2013.
Article
in English
| WPRIM
| ID: wpr-812320
ABSTRACT
AIM@#To identify and quantify the major metabolites of salvianolic acid B (SAB) after intravenous injection in rats.@*METHODS@#LC-IT/TOF-MS was used to identify the metabolites in rat bile, plasma, and urine; LC-MS/MS was used to quantify the two major metabolites.@*RESULTS@#In rat bile, plasma, and urine, nine metabolites were identified, including methylated metabolites of SAB, lithospermic acid (LSA), the decarboxylation and methylation metabolites of LSA, salvianolic acid S (SAS), and dehydrated-SAS. The t1/2 of monomethyl-SAB and LSA were both very short, and monomethyl-SAB had a larger AUC than LSA in rats.@*CONCLUSION@#Nine metabolites were found, the metabolic pathway was described, and the pharmacokinetic profiles of LSA and monomethyl-SAB were studied, thereby clarifying that methylation was the dominant metabolic pathway for SAB in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Urine
/
Benzofurans
/
Bile
/
Pharmacokinetics
/
Molecular Structure
/
Chemistry
/
Rats, Sprague-Dawley
/
Administration, Intravenous
/
Metabolism
Type of study:
Diagnostic study
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2013
Type:
Article
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