Chemical constituents from Gnaphalium affine and their xanthine oxidase inhibitory activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 347-353, 2018.
Article
in English
| WPRIM
| ID: wpr-812396
ABSTRACT
Gnaphalium affine D. Don, a medicinal and edible plant, has been used to treat gout in traditional Chinese medicine and popularly consumed in China for a long time. A detailed phytochemical investigation on the aerial part of G. affine led to the isolation of two new esters of caffeoylquinic acid named (-) ethyl 1, 4-di-O-caffeoylquinate (1) and (-) methyl 1, 4-di-O-caffeoylquinate (2), together with 35 known compounds (3-37). Their structures were elucidated by spectroscopic data and first-order multiplet analysis. All the isolated compounds were tested for their xanthine oxidase inhibitory activity with an in vitro enzyme inhibitory screening assay. Among the tested compounds, 1 (IC 11.94 μmol·L) and 2 (IC 15.04 μmol·L) showed a good inhibitory activity. The current results supported the medical use of the plant.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Quinic Acid
/
Xanthine Oxidase
/
Flavonoids
/
Drugs, Chinese Herbal
/
Plant Extracts
/
Adenine
/
Molecular Structure
/
Chemistry
/
Gout Suppressants
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2018
Type:
Article
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