Fumigaclavine I, a new alkaloid isolated from endophyte Aspergillus terreus / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 937-941, 2015.
Article
in En
| WPRIM
| ID: wpr-812461
Responsible library:
WPRO
ABSTRACT
The present study was designed to isolate and purify chemical constituents from solid culture of endophyte Aspergillus terreus LQ, using silica gel column chromatography, gel filtration with Sephadex LH-20, and HPLC. Fumigaclavine I (1), a new alkaloid, was obtained, along with seven known compounds, including fumigaclavine C (2), rhizoctonic acid (3), monomethylsulochrin (4), chaetominine (5), spirotryprostatin A (6), asperfumoid (7), and lumichrome (8). The structure of compound 1 was elucidated by various spectroscopic analyses (UV, MS, 1D and 2D NMR). The in vitro cytotoxicity of compound 1 was determined by MTT assay in human hepatocarcinoma cell line SMMC-7721, showing weaker cytotoxicity, compared with cisplatin, a clinically used cancer chemotherapeutic agent.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Aspergillus
/
Oryza
/
Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Cell Survival
/
Chemistry
/
Cell Line, Tumor
/
Ergot Alkaloids
/
Endophytes
/
Microbiology
Limits:
Humans
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2015
Type:
Article