Diversity synthesis of tetrahydroprotoberberines glycosides by combined chemical and microbial catalysis / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 783-788, 2016.
Article
in En
| WPRIM
| ID: wpr-812557
Responsible library:
WPRO
ABSTRACT
The present study was designed to construct the structurally diverse library of tetrahydroprotoberberines (THPBs) by combining the methods of chemical nonselective demethylation and microbial glycosylation. HPLC-MS/MS analyses tentatively identified 12 de-methylated and 9 glycosylated derivates of THPBs and 5 rarely oxidized glycosides of THPBs in the library. Through this effort, we achieved not only a variety of the THPBs and their glycosides but also tested the catalytic characteristics and capabilities of G. deliquescens NRRL 1086.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Berberine Alkaloids
/
Glycosylation
/
Biotransformation
/
Molecular Structure
/
Catalysis
/
Chemistry
/
Gliocladium
/
Glycosides
/
Metabolism
Type of study:
Prognostic_studies
Language:
En
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2016
Type:
Article