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Diversity synthesis of tetrahydroprotoberberines glycosides by combined chemical and microbial catalysis / 中国天然药物
Article in En | WPRIM | ID: wpr-812557
Responsible library: WPRO
ABSTRACT
The present study was designed to construct the structurally diverse library of tetrahydroprotoberberines (THPBs) by combining the methods of chemical nonselective demethylation and microbial glycosylation. HPLC-MS/MS analyses tentatively identified 12 de-methylated and 9 glycosylated derivates of THPBs and 5 rarely oxidized glycosides of THPBs in the library. Through this effort, we achieved not only a variety of the THPBs and their glycosides but also tested the catalytic characteristics and capabilities of G. deliquescens NRRL 1086.
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Full text: 1 Index: WPRIM Main subject: Berberine Alkaloids / Glycosylation / Biotransformation / Molecular Structure / Catalysis / Chemistry / Gliocladium / Glycosides / Metabolism Type of study: Prognostic_studies Language: En Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2016 Type: Article
Full text: 1 Index: WPRIM Main subject: Berberine Alkaloids / Glycosylation / Biotransformation / Molecular Structure / Catalysis / Chemistry / Gliocladium / Glycosides / Metabolism Type of study: Prognostic_studies Language: En Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2016 Type: Article