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Two new limonoids isolated from the fuits of Melia toosendan / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 692-696, 2016.
Article in English | WPRIM | ID: wpr-812576
ABSTRACT
In the present study, two new limonoids, 1α, 7α-dihydroxyl-3α-acetoxyl-12α-ethoxylnimbolinin (1) and 1α-tigloyloxy-3α-acetoxyl-7α-hydroxyl-12β-ethoxylnimbolinin (2), together with other four known limonoids (3-6), were isolated from the fruits of Melia toosendan. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and ESI-MS) and comparisons with the data reported in the literature. The isolated compounds were evaluated for their antibacterial activities. Compound 4 exhibited significant antibacterial activity against an oral pathogen, Porphyromonas gingivalis ATCC 33277, with an MIC value of 15.2 μg·mL(-1). Compound 2 was also active against P. gingivalis ATCC 33277, with an MIC value of 31.25 μg·mL(-1). In conlcusion, our resutls indicate that these compounds may provide a basis for future development of novel antibiotics.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Drugs, Chinese Herbal / Magnetic Resonance Spectroscopy / Molecular Structure / Chemistry / Porphyromonas gingivalis / Spectrometry, Mass, Electrospray Ionization / Melia / Limonins / Fruit Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Drugs, Chinese Herbal / Magnetic Resonance Spectroscopy / Molecular Structure / Chemistry / Porphyromonas gingivalis / Spectrometry, Mass, Electrospray Ionization / Melia / Limonins / Fruit Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2016 Type: Article