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Epimedium koreanum Nakai and its main constituent icariin suppress lipid accumulation during adipocyte differentiation of 3T3-L1 preadipocytes / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 671-676, 2016.
Article in English | WPRIM | ID: wpr-812579
ABSTRACT
Obesity is associated with a number of metabolic abnormalities such as type 2 diabetes and has become a major health problem worldwide. In the present study, we investigated the effects of Epimedium koreanum Nakai (Herba Epimedii, HE) and its main constituent icariin on the adipocyte differentiation in 3T3-L1 preadipocytes. HE extract and icariin significantly reduced lipid accumulation and suppressed the expressions of PPARγ, C/EBPα, and SREBP-1c in 3T3-L1 adipocytes. They also inhibited fatty acid synthase (FAS), acyl-Co A synthase (ACS1), and perilipin. Moreover, HE extract and icariin markedly increased the phosphorylation of AMPK. These results indicated that HE extract and icariin can inhibit the adipocyte differentiation through downregulation of the adipogenic transcription factors, suggesting that HE containing icariin may be used as a potential therapeutic agent in the treatment and prevention of obesity.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Flavonoids / Plant Extracts / Chemistry / Adipocytes / CCAAT-Enhancer-Binding Protein-alpha / Cell Biology / Epimedium / 3T3-L1 Cells / PPAR gamma Limits: Animals Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Flavonoids / Plant Extracts / Chemistry / Adipocytes / CCAAT-Enhancer-Binding Protein-alpha / Cell Biology / Epimedium / 3T3-L1 Cells / PPAR gamma Limits: Animals Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2016 Type: Article