Reproductive toxicity of brazilein in ICR mice / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 441-448, 2016.
Article
in English
| WPRIM
| ID: wpr-812612
ABSTRACT
Brazilein is an active small molecular compound extracted from Caesalpinia sappan L. with favorable pharmacological properties on immune system, cardiovascular system, and nervous system. C. sappan has been used as a traditional medicine in China for hundreds of years for various diseases. However, the general reproductive toxicity of brazilein is still unknown. The purpose of the present study was to thoroughly evaluate the general reproductive toxicity of brazilein in ICR mice to support the future drug development and modernization of this potent traditional Chinese medicine. The results showed that, although no apparent toxicity on the reproducibility of the male was observed, brazilein might cause considerable risks to the fetuses and females as indicated by the ratios of dead fetuses and reabsorptions. In conclusion, our results from the present study provided some useful insights about the safety profile of brazilein, suggesting that brazilein should be used with caution in pregnant women.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reproduction
/
Benzopyrans
/
Drugs, Chinese Herbal
/
Caesalpinia
/
Toxicity
/
Indenes
/
Mice, Inbred ICR
Limits:
Animals
/
Pregnancy
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2016
Type:
Article
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