Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 427-433, 2016.
Article
in English
| WPRIM
| ID: wpr-812614
ABSTRACT
Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating β-amyloid (Aβ) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of Aβ toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on Aβ toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychology
/
Plant Extracts
/
Chemistry
/
Amyloid beta-Peptides
/
Caenorhabditis elegans
/
Dietary Supplements
/
Vaccinium macrocarpon
/
Disease Models, Animal
/
Drug Therapy
/
Toxicity
Type of study:
Practice guideline
/
Prognostic study
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2016
Type:
Article
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