Two novel resin glycosides isolated from Ipomoea cairica with α-glucosidase inhibitory activity / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 227-231, 2016.
Article
in English
| WPRIM
| ID: wpr-812632
ABSTRACT
In the present study, two new compounds from Ipomoea cairica were identified and demonstrated to have α-glucosidase inhibitory activity. They were isolated by column chromatography on silica gel and sephadex LH-20 and finally purified by prep-HPLC, with their structures being elucidated by spectroscopic methods, such as 1D- and 2D-NMR and HR-TOF-MS, and chemical methods. Compounds 1 and 2, named cairicoside A and cairicoside B, were evaluated for α-glucosidase inhibitory activity by the MTT method, with the IC50 values being 25.3 ± 1.6 and 28.5 ± 3.3 μmol·L(-1), respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Resins, Plant
/
Spectrum Analysis
/
Plant Extracts
/
Molecular Structure
/
Chemistry
/
Ipomoea
/
Alpha-Glucosidases
/
Glycoside Hydrolase Inhibitors
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2016
Type:
Article
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