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A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata / 中国天然药物
Article in English | WPRIM | ID: wpr-812661
Responsible library: WPRO
ABSTRACT
AIM@#To study the Amaryllidaceae alkaloids of the bulbs of Lycoris radiata.@*METHODS@#The chemical constituents were isolated and purified by various chromatographic techniques, and the chemical structures were elucidated on the basis of spectroscopic methods. In addition, the antiviral activities of alkaloids 1-10 were evaluated using flu virus A.@*RESULTS@#One new homolycorine-type alkaloid 2α-methoxy-6-O-ethyloduline (1), together with nine known alkaloids 2α-methoxy-6-O-methyloduline (2), trispherine (3), 8-O-demethylhomolycorine (4), homolycorine (5), 9-O-demethylhomolycorine (6), oduline (7), lycorenine (8), 6α-O-methyllycorenine (9) and O-ethyllycorenine (10) were obtained.@*CONCLUSION@#Alkaloid 1 is a new compound, and 1-3 were major alkaloids in this plant. Alkaloids 1-3 showed weak antiviral activities against flu virus A with IC50 values of 2.06, 0.69, and 2.71 μg·mL-1 and CC50 values of 14.37, 4.79, and 80.12 μg·mL-1, respectively.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Influenza A virus / Pharmacology / Plant Extracts / Molecular Structure / Chemistry / Lycoris / Flowers / Alkaloids Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Antiviral Agents / Influenza A virus / Pharmacology / Plant Extracts / Molecular Structure / Chemistry / Lycoris / Flowers / Alkaloids Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2013 Type: Article