Hepatoprotective effects of Astragalus kahiricus root extract against ethanol-induced liver apoptosis in rats / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 354-361, 2013.
Article
in English
| WPRIM
| ID: wpr-812669
ABSTRACT
The hepatoprotective activity of the ethanol extract of Astragalus kahiricus (Fabaceae) roots against ethanol-induced liver apoptosis was evaluated and it showed very promising hepatoprotective actions through different mechanisms. The extract counteracted the ethanol-induced liver enzymes leakage and glutathione depletion. In addition, it demonstrated anti-apoptotic effects against caspase-3 activation and DNA fragmentation that were confirmed by liver histopathological examination. Moreover, the phytochemical study of this extract led to the isolation of four cycloartane-type triterpenes identified as astrasieversianin II (1), astramembrannin II (2), astrasieversianin XIV (3), and cycloastragenol (4). The structures of these isolates were established by HRESI-MS and 1D and 2D NMR experiments. The antimicrobial, antimalarial, and cytotoxic activities of the isolates were further evaluated, but none of them showed any activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plant Extracts
/
Chemistry
/
Rats, Sprague-Dawley
/
Apoptosis
/
Plant Roots
/
Protective Agents
/
Astragalus Plant
/
Cell Biology
/
Ethanol
/
Drug Therapy
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2013
Type:
Article
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