A pair of sulfonated diarylheptanoid epimers from Kaempferia galanga / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 171-176, 2013.
Article
in English
| WPRIM
| ID: wpr-812676
ABSTRACT
AIM@#To discover new bioactive constituents from Kaempferia galanga L. (Zingiberaceae).@*METHODS@#The extract of K. galanga was divided into the chloroform and water-soluble portions. The latter fraction was successively subjected to column chromatography over a D101 macroporous adsorption resin, MCI, Sephadex LH-20, and preparative HPLC to obtain two compounds.@*RESULTS@#Two novel sulfonated diarylheptanoid epimers, namely kaempsulfonic acids A (1) and B (2), were isolated from the rhizomes of K. galanga. Their structures were established by analysis of spectroscopic data. The absolute configurations of 1 and 2 were determined by the comparison of experimental electronic circular dichroism (ECD) spectroscopy and the computational calculation method, combined with Mo2(OAc)4 induced circular dichroism (ICD).@*CONCLUSION@#The isolates 1 and 2 are new compounds and their absolute configurations were determined for the first time.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plant Extracts
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Zingiberaceae
/
Rhizome
/
Diarylheptanoids
/
Isomerism
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2013
Type:
Article
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