Effects of Kudzu Root plus Cinnamon Granules on prostatic hyperplasia in mice / 中华男科学杂志
National Journal of Andrology
;
(12): 353-360, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-812760
ABSTRACT
Objective@#To explore the effects of Kudzu Root plus Cinnamon Granules (KR+C) on prostatic hyperplasia (PH) in mice.@*METHODS@#Sixty 4-week-old Kunming male mice were randomly divided into six groups blank control, PH model, high-, medium- and low-dose KR+C, and finasteride control. All the mice except those in the blank control group were subcutaneously injected with testosterone propionate (5 mg / [kg·d]) at 7 days after surgical castration. The animals of different groups were treated intragastrically with different doses of KR+C, finasteride, and normal saline respectively for 3 weeks and then sacrificed for weighing of the prostate, calculation of the prostatic index, observation of the morphological changes in the prostate after HE staining, determination of the expressions of FGF2, Ki67 and TGF-β1 by immunohistochemistry, detection of 5α-reductase activity by ELISA, and measurement of the apoptosis index of the prostatic cells by TUNEL.@*RESULTS@#Compared with the model controls, the mice of the other groups showed significantly reduced prostatic volume (P 0.05).@*CONCLUSIONS@#KR+C can reduce the prostatic volume of PH mice by decreasing the activity of 5α- reductase, inhibiting the expressions of FGF2, Ki67 and TGF-β1, and promoting the apoptosis of prostatic cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Pathology
/
Prostate
/
Prostatic Hyperplasia
/
Random Allocation
/
Chemistry
/
Fibroblast Growth Factor 2
/
Cinnamomum zeylanicum
/
Apoptosis
/
Finasteride
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS