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Qilin Pills for idiopathic oligoasthenospermia: A multi-centered randomized double-blind controlled clinical trial / 中华男科学杂志
National Journal of Andrology ; (12): 251-255, 2017.
Article in Chinese | WPRIM | ID: wpr-812777
ABSTRACT
Objective@#To evaluate the clinical efficacy and safety of Qilin Pills in the treatment of oligoasthenospermia in infertile men.@*METHODS@#This multi-centered randomized double-blind controlled clinical trial included 216 infertile males with oligoasthenospermia, 108 in the trial group and the other 108 in the control, the former treated with Qilin Pills at the dose of 6 g tid while the latter with Wuziyanzong Pills at 6 g bid, both for 12 weeks. We examined the total sperm count, sperm motility and the count of progressively motile sperm of the patients before and at 4, 8 and 12 weeks after medication and evaluated the safety of the drug based on the adverse events and the laboratory results of blood and urine routine examinations and liver and kidney function tests.@*RESULTS@#Compared with the baseline, the patients in the trial group showed a significant time-dependent improvement after 4, 8 and 12 weeks of medication in sperm motility (21.75% vs 27.54%, 29.04% and 32.95%, P <0.05), total sperm count (156.27 ×106 vs 177.33, 188.18 and 205.44 ×106, P <0.05), and the count of progressively motile sperm (32.08 ×10⁶/ml vs 46.33, 50.98 and 61.10 ×10⁶/ml, P <0.05). The three parameters above were also improved in the controls, but more significantly in the trial group (P <0.05).@*CONCLUSIONS@#Qilin Pills can evidently improve the semen quality of oligoasthenospermia patients with no obvious adverse events.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oligospermia / Sperm Count / Sperm Motility / Capsules / Drugs, Chinese Herbal / Double-Blind Method / Treatment Outcome / Therapeutic Uses / Drug Therapy / Asthenozoospermia Type of study: Controlled clinical trial Limits: Humans / Male Language: Chinese Journal: National Journal of Andrology Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Oligospermia / Sperm Count / Sperm Motility / Capsules / Drugs, Chinese Herbal / Double-Blind Method / Treatment Outcome / Therapeutic Uses / Drug Therapy / Asthenozoospermia Type of study: Controlled clinical trial Limits: Humans / Male Language: Chinese Journal: National Journal of Andrology Year: 2017 Type: Article