Single nucleotide polymorphism of the TP53 gene is not correlated with male infertility / 中华男科学杂志
National Journal of Andrology
;
(12): 142-146, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-812796
ABSTRACT
Objective@#To investigate the correlation of the single nucleotide polymorphism (SNP) rs1042522 of the tumor protein p53 (TP53) gene with the risk of male infertility.@*METHODS@#This casecontrol study included 380 male patients with idiopathic infertility and 398 normal fertile men as controls from the Nanjing area. We genotyped the SNP rs1042522 of the TP53 gene by Sequence Mass Array and analyzed the correlation of the SNP with male infertility using the logistic regression model.@*RESULTS@#Compared with the normal controls, the patients with idiopathic infertility showed significantly decreased sperm concentration ([77.34±49.24] vs [13.13±24.96] ×106/ml), percentage of progressively motile sperm ([42.55±9.57] vs [10.38±5.57]%), serum testosterone level ([14.07±5.36] vs [11.89±4.50] nmol/L), and folliclestimulating hormone level ([16.80±18.20] vs [4.55±7.17] U/L) (P < 0.05) but no statistically significant differences in other parameters. No correlation was observed between the SNP frequencies and male infertility and similar results were found in the subgroups of the cases.@*CONCLUSIONS@#SNP rs1042522 of the TP53 gene is not significantly correlated with the risk of male infertility.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sperm Count
/
Sperm Motility
/
Testosterone
/
Blood
/
Case-Control Studies
/
Logistic Models
/
Genes, p53
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Follicle Stimulating Hormone
Type of study:
Observational study
/
Risk factors
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2017
Type:
Article
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