Huangjing Zanyu Capsule enhances sperm mitochondrial membrane potential in asthenozoospermia patients / 中华男科学杂志
National Journal of Andrology
;
(12): 1116-1120, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-812823
ABSTRACT
Objective@#To observe the effect of Huangjing Zanyu Capsule (HZC) on sperm mitochondrial membrane potential (MMP) in asthenozoospermia patients.@*METHODS@#We assigned 70 asthenozoospermia patients to a treatment group (n = 39) and a control group (n = 31), the former treated with oral HZC at the dose of 4 capsules tid for 3 months while the latter left untreated. We obtained semen parameters from the patients and detected their sperm mitochondrial membrane potentials (MMP) by JC-1 staining and flow cytometry before and after medication, followed by comparison between the two groups.@*RESULTS@#The total effectiveness rate was 71.05% in the treatment group and natural pregnancy was achieved in 3 cases during the medication. A total of 35 patients in the treatment group and 30 controls completed all the laboratory examinations after a 3-month observation. Compared with the controls, the patients treated with HZC exhibited significant improvement after medication in MMP (variation value [1.19 ± 10.36]% vs [20.28 ± 14.21]%, P <0.01), total sperm motility (variation value [3.46 ± 8.67]% vs [20.68 ± 14.12]%, P <0.01), the percentage of progressively motile sperm (variation value [2.26 ± 8.29]% vs [17.58 ± 12.73]%, P <0.01), and the percentage of morphologically normal sperm (variation value [0.23 ± 3.48]% vs [3.37 ± 3.99]%, P <0.01). MMP was significantly correlated with total sperm motility (r = 0.69, P <0.01), progressive sperm motility (r = 0.75, P <0.01) and normal sperm morphology (r = 0.26, P <0.01).@*CONCLUSIONS@#Huangjing Zanyu Capsule can enhance sperm mitochondrial membrane potential and sperm mitochondrial function, thus improving total sperm motility, progressive sperm motility and normal sperm morphology. It is safe and effective for the treatment of asthenospermia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Semen
/
Sperm Motility
/
Spermatozoa
/
Staining and Labeling
/
Capsules
/
Drugs, Chinese Herbal
/
Case-Control Studies
/
Therapeutic Uses
/
Drug Therapy
Type of study:
Observational study
Limits:
Female
/
Humans
/
Male
/
Pregnancy
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2017
Type:
Article
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