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Cholinergic anti-inflammatory pathway and its role in treatment of sepsis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 68-73, 2020.
Article in English | WPRIM | ID: wpr-812986
ABSTRACT
The cholinergic anti-inflammatory pathway (CAP) is a neuro-immunomodulatory pathway,in which acetylcholine (ACh) released by the interaction of vagal nerves with α7 nicotinic acetylcholine receptor (α7nAChR),which prevents the synthesis and release of pro-inflammatory cytokines and ultimately regulates the local or systemic inflammatory response in a feedback manner. It has been shown that there are many possible effective treatments for sepsis, including vagus nerve stimulation by physical therapy, drugs such as acetylcholine receptor agonist and ultrasound therapy.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Neuroimmunomodulation / Acetylcholine / Sepsis / Vagus Nerve Stimulation / Alpha7 Nicotinic Acetylcholine Receptor / Inflammation Limits: Humans Language: English Journal: Journal of Central South University(Medical Sciences) Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Neuroimmunomodulation / Acetylcholine / Sepsis / Vagus Nerve Stimulation / Alpha7 Nicotinic Acetylcholine Receptor / Inflammation Limits: Humans Language: English Journal: Journal of Central South University(Medical Sciences) Year: 2020 Type: Article