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Clinical observation for NAPD regimen in the treatment of 67 cases of recurrent refractory non-Hodgkin's lymphoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 46-52, 2019.
Article in Chinese | WPRIM | ID: wpr-813079
ABSTRACT
To explore the clinical efficacy and toxicity of the NAPD regimen(vinorelbine, cytarabine, cisplatin, and dexamethasone) in the treatment of recurrent refractory non-Hodgkin' s lymphoma.


Methods:

A total of 67 patients identified with recurrent refractory non-Hodgkin's lymphoma were enrolled for this retrospective study. The curative efficacy of NAPD regimen was evaluated after 2 consecutive cycles. The toxicities and side effects were evaluated after 1 cycle. The objective response rate (ORR), overall survival (OS), progress free survival (PFS), 1, 2 or 4 years of OS and PFS rates were analyzed. The prognosis was evaluated with univariate and multivariate analysis.


Results:

The ORR was 53.8% after two cycles, including 5(7.5%) complete responses and 31(46.3%) partial responses. The clinical benefit rate (CBR) was 88.7% (59/67). The median OS was 22 (1.5-140.0) months. 1, 2 or 4 years of OS rates were 70.9%, 49.0%, and 35.0%, respectively. The median PFS was 14 (1.5-140.0) months; and 1, 2 or 4 years of PFS rates were 57.5%, 38.3%, and 29.8%, respectively. The main side effect was myelosuppression. The rates of Grade III/IV leukopenia and thrombocytopenia were 13.4% (9 cases) and 3.0% (2 cases), respectively. Gastrointestinal toxicity was at Grade I or II and 6% patients displayed gastrointestinal toxicity at Grade III/IV. No severe cardiac and hepatorenal functional toxicity was observed.


Conclusion:

The NAPD regimen for recurrent refractory non-Hodgkin's lymphoma is effective, and its toxicity is well tolerated. It is a salvage chemotherapy regimen and be of worth to be verified.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Lymphoma, Non-Hodgkin / Dexamethasone / Antineoplastic Combined Chemotherapy Protocols / Retrospective Studies / Cisplatin / Treatment Outcome / Salvage Therapy / Drug Therapy / Etoposide / Neoplasm Recurrence, Local Type of study: Observational study Limits: Humans Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Lymphoma, Non-Hodgkin / Dexamethasone / Antineoplastic Combined Chemotherapy Protocols / Retrospective Studies / Cisplatin / Treatment Outcome / Salvage Therapy / Drug Therapy / Etoposide / Neoplasm Recurrence, Local Type of study: Observational study Limits: Humans Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2019 Type: Article