Differential expression of lncRNA in patients with coronary artery disease plus clopidogrel resistance / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 9-13, 2019.
Article
in Zh
| WPRIM
| ID: wpr-813084
Responsible library:
WPRO
ABSTRACT
To explore differential expression of long non-coding RNA (lncRNA) in patients with coronary artery disease plus clopidogrel resistance.
Methods: Patients underwent percutaneous coronary intervention (PCI) and treated with clopidogrel were recruited, and their clinical data and blood samples were collected. Patients were divided into a clopidogrel sensitive group and a clopidogrel resistance group according to platelet aggregation rate. lncRNA microarray and real-time RT-PCR were performed in 5 and 34 patients in each group, respectively.
Results: lncRNA microarray showed that 11 lncRNAs in peripheral leukocytes were up-regulated and 8 lncRNAs were down-regulated in clopidogrel resistant group. Real-time PCR indicated that two lncRNAs (NONHSAT083775.2 and NONHSAT107804.2) in leukocytes were up-regulated and one lncRNA (NONHSAT133455.2) was down-regulated in the clopidogrel resistant group compared with the clopidogrel sensitive group, consistent with the results of lncRNA microarray.
Conclusion: Clopidogrel resistance is associated with the up-regulation of lncRNA NONHSAT083775.2 and NONHSAT107804.2 and the down-regulation of NONHSAT133455.2.
Full text:
1
Index:
WPRIM
Main subject:
Coronary Artery Disease
/
Platelet Aggregation Inhibitors
/
Platelet Aggregation
/
RNA, Long Noncoding
/
Percutaneous Coronary Intervention
/
Clopidogrel
/
Genetics
Limits:
Humans
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2019
Type:
Article