Early diagnosis, prevention and treatment for calcific uremic arteriolopathy / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1251-1256, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-813107
ABSTRACT
Calcific uremic arteriopathy (CUA), termed calciphylaxis, is a rare but highly fatal clinical syndrome. There is no clearly laboratory diagnostic criteria for CUA. The medium and small arterial calcification and microthrombosis discovered by skin biopsy, radiologic imaging,bone scan and the evidence of activation of the bone morphogenetic protein signal (BMPs) transduction pathway are useful for early diagnosis of this disease. The common therapies (including intravenous sodium thiosulfate (STS) and bisphosphonates, hyperbaric oxygen therapy and other symptomatic supports) are used for the management of wounds, pain, nutrition, dialysis and so on. Controlling the chronic kidney disease-mineral and bone disorder (CKD-MBD) and some complications of dialysis and drugs (such as warfarin, active vitamin D) can prevent CUA. However, CUA patients still have poor prognosis and high mortality. Since some patients progress rapidly, it is of great importance to make early diagnosis and provide effective treatments with multidisciplinary management.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Uremia
/
Warfarin
/
Calciphylaxis
/
Renal Dialysis
/
Early Diagnosis
/
Diagnosis
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2018
Type:
Article
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