Recent progress in smooth muscle autophagy of vascular diseases / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 920-928, 2018.
Article
in Zh
| WPRIM
| ID: wpr-813172
Responsible library:
WPRO
ABSTRACT
Autophagy plays a crucial role in maintaining normal structure and vascular function in vivo. When stress-relevant stimuli are involved, the increases of autophagy can protect vascular smooth muscle cells, promote cell survival, and phenotype transformation, as well as reduce calcification. On the contrary, the decrease of autophagy can accelerate cell senescence, resulting in structural changes and dysfunction of vasomotor and vasodilation. However, excessive activation of autophagy can induce the damage of the healthy protein and essential organelles, and even lead to autophagic cell death, accelerating the progression of vascular disease. Thus, the precise targeting of autophagy opens a novel way for treatment of vascular diseases.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Physiology
/
Autophagy
/
Therapeutics
/
Vascular Diseases
/
Cell Survival
/
Cellular Senescence
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Disease Progression
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Cell Biology
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Myocytes, Smooth Muscle
Limits:
Humans
Language:
Zh
Journal:
Journal of Central South University(Medical Sciences)
Year:
2018
Type:
Article