Research progress in PRAS40 / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 685-690, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-813210
ABSTRACT
Prolin-rich Akt substrate of 40 kD (PRAS40) is firstly identified as a partner of 14-3-3 protein and a substrate of Akt kinase by Roth et al in 2003. Accumulated evidence shows that PRAS40 is mainly activated by phosphorylate modification at different sites. PRAS40 may be involved in various of signaling pathways, such as mammalian target of rapamycin complex 1 (mTORC1), protein kinase B (Akt), NF-κB and ribosomal protein L11 (RPL11) etc, which can regulate cell proliferation, senescence, autophagy, apoptosis and exosome secretion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Adaptor Proteins, Signal Transducing
/
Proto-Oncogene Proteins c-akt
/
TOR Serine-Threonine Kinases
/
Mechanistic Target of Rapamycin Complex 1
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2018
Type:
Article
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