Application of intravoxel incoherent motion diffusion weighted imaging for assessment of early chronic allograft nephropathy / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 501-506, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-813274
ABSTRACT
To investigate the feasibility and clinical application of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) technique in non-invasive assessment for early chronic allograft nephropathy (CAN).
Methods:
A total of 23 renal allograft recipients were recruited from inpatients or outpatients according to the inclusion and exclusion criteria for this study. Recipients were divided into a CAN group (n=12, pathologically confirmed early CAN patients) and a control group (n=11, volunteers with long-term stable renal function). Abdominal MRI was performed on patients of renal allograft with a multi-b value DWI sequence. IVIM2b-new software was used for obtaining the IVIM-DWI quantitative parameter pseudo-color maps and the values of IVIM-DWI of renal parenchyma, including the pure diffusion coefficient (D), perfusion correlation diffusion coefficient (D*) and perfusion fraction (f). The IVIM quantitative parameters between the two groups were compared using independent sample t test. ROC analysis was performed when the differences in parameter were statistically significant and the area under curve (AUC) was calculated.Results:
In IVIM bi-exponential analysis, The D value was significantly decreased in the CAN group compared with the control group (P0.05). The AUC of D value for distinguishing the early CAN from the control were 0.784 with sensitivity and specificity at 58.3% and 90.9%, respectively.Conclusion:
The IVIM-DWI quantitative parameter D can non-invasively assess early CAN to some extent. IVIM-DWI technique is expected to be an effective, easy and non-invasive method to detect early CAN, and assist early diagnose as well as dynamically monitor CAN.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
General Surgery
/
Magnetic Resonance Imaging
/
Kidney Transplantation
/
Diffusion Magnetic Resonance Imaging
/
Allografts
/
Kidney Diseases
/
Motion
Limits:
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2019
Type:
Article
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