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Structure and function of DJ-1 and its role in Parkinson's disease / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences) ; (12): 105-111, 2019.
Article in Chinese | WPRIM | ID: wpr-813313
ABSTRACT
Parkinson's disease (PD) is a neurodegenerative movement disorder mainly due to degeneration of dopaminergic neurons in the substantia nigra. Most PD cases are sporadic and only 5%-10% of patients carry mutations with inheritance. Among them, the mutation of DJ-1 is related to the autosomal recessive early-onset parkinsonism. DJ-1, the Parkinson's disease-related protein, plays important roles in different physiopathological processes, including oxidative stress, cell translocation and regulation of transcription and translation. DJ-1 is known to be widely expressed in different areas of brain, including hippocampus, amygdala, substantia nigra and cortical areas. Several researchers have tried to demonstrate the clinical and neuroimaging features of DJ-1 related parkinsonism. The DJ-1 knockout mouse model was established to further explore the mechanisms of different functions. Moreover, the search for different forms of DJ-1 as potential biomarkers of PD also provides guidance for its accurate diagnosis and treatment in the future.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Parkinson Disease / Substantia Nigra / Oncogene Proteins / Oxidative Stress / Dopaminergic Neurons / Protein Deglycase DJ-1 Type of study: Practice guideline Limits: Animals Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Parkinson Disease / Substantia Nigra / Oncogene Proteins / Oxidative Stress / Dopaminergic Neurons / Protein Deglycase DJ-1 Type of study: Practice guideline Limits: Animals Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2019 Type: Article