Research progress in the role of microRNA-155 in regulation of autophagy and diagnosis and treatment for gastric cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 87-91, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-813316
ABSTRACT
China is one of the regions with a high incidence of gastric cancer worldwide. Low detection rate and poor curative effect lead to unsatisfied prognosis and low five-year survival rate. Surgery combined with radiotherapy and chemotherapy is the mainstream comprehensive treatment scheme, however, multi-drug resistance may gradually prevail in the chemotherapy process. Chemotherapy, miRNA and autophagy interact with each other, but the mechanism is complex. MiR-155 is abnormally expressed in gastric cancer, which could promote autophagy, inhibit apoptosis, and interact with Helicobacter pylori to induce gastric cancer. Through its regulatory effect on autophagy, miR-155 can be used to treat gastric cancer, improve chemotherapy sensitivity and reverse drug resistance. The high expression of miR-155 in gastric cancer tissues suggests poor prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autophagy
/
Stomach Neoplasms
/
Gene Expression Regulation, Neoplastic
/
China
/
MicroRNAs
/
Cell Line, Tumor
/
Genetics
Type of study:
Diagnostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2019
Type:
Article
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