Microvessel counts and the expressions of chemotactic factors in the pathological scar tissues / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 340-348, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-813366
ABSTRACT
OBJECTIVE@#To explore the microvessel counts and the expressions of interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1 ( MIP-1) alpha mRNA in the pathological scar tissues.@*METHODS@#Immunohistochemical method of avidin-biotin complex was used for microvessel counts on the routinely formalin-fixed and paraffin-embedded sections of specimens of hypertrophic scars, keloids, normal skin, and surgical scar, and in situ hybridization for the expressions of IL-8, MCP-1, MIP-1alpha mRNA.@*RESULTS@#The microvessel counts as well as the positive rates and the scorings of IL-8, MCP-1, and MIP-1alpha mRNA were significantly higher in pathological scars than those in the normal skin and surgical scar (all P < 0.05). The microvessel counts were significantly higher in the positive cases of IL-8, MCP-1 and MIP-1alpha mRNA than those in the negative ones (P < 0.05). The close positive correlations were found among the microvessel counts and the expressive scorings of 3 factors (P < 0.05). The close positive correlations were also found among the expressive scorings of IL-8, MCP-1, and MIP-1alpha mRNA in pathological scars. Microvessel counts were significantly higher in hypertrophic scars with the course less than 1 year than those with the course more than 1 year.@*CONCLUSION@#IL-8, MCP-1 and MIP-1alpha play important roles in promoting the neovascularization of pathological scars.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
Burns
/
Capillaries
/
RNA, Messenger
/
Interleukin-8
/
Cicatrix
/
Chemokine CCL2
/
Macrophage Inflammatory Proteins
/
Chemokine CCL3
/
Chemokine CCL4
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2005
Type:
Article
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