Expression and significance of PTEN and nm23 in the metastasis of gallbladder cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 46-48, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-813423
ABSTRACT
OBJECTIVE@#To explore the relationship between the expressions of PTEN and the metastasis of the gallbladder cancer.@*METHODS@#The expression of PTEN and nm23 were detected by immunohistochemical staining in 32 cases of gallbladder cancer with metastasis and the staining intensity was scored semi-quantitatively, compared with the cases without metastasis.@*RESULTS@#The intensity score of PTEN and nm23 in gallbladder cancer with metastasis was 8.9947+/-4.5590 and 10.2003+/-3.9031, respectively, which was lower than that in those without metastasis (12.9433+/-4.7618 and 15.8436+/-5.6917 respectively, P < 0.01 ). The expression of PTEN was correlative with that of nm23 ( Pearson = 0.370, P < 0.05).@*CONCLUSION@#The lower expressions of PTEN and nm23 are related to the metastasis of gallbladder cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Nucleoside-Diphosphate Kinase
/
Tumor Suppressor Proteins
/
PTEN Phosphohydrolase
/
NM23 Nucleoside Diphosphate Kinases
/
Gallbladder Neoplasms
/
Genetics
/
Liver Neoplasms
/
Lymphatic Metastasis
/
Metabolism
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2005
Type:
Article
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