Expression of matrix metalloproteinase 2 in oral verruvous carcinoma and squamous cell carcinoma / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To determine the expression of MMP2 mRNA in oral verruvous carcinoma and squamous cell carcinoma.@*METHODS@#Thirty cases were divided into 3 groups verruvous carcinoma (n = 10), well-differentiated squamous cell carcinoma (n = 15) and moderately or poorly differentiated squamous cell carcinoma (n = 5). Reverse transcription polymerase chain reaction (RT-PCR) was used to test the expression of MMP2 mRNA in the carcinoma tissues and matched normal tissues from 3 groups above.@*RESULTS@#The expression of MMP2 mRNA in the carcinoma tissues was significantly higher than that in their matched normal tissues (P 0.05).@*CONCLUSION@#The expression of MMP2 mRNA in oral verruvous carcinoma and squamous cell carcinoma tissues was significantly higher than that in their matched normal tissues. The expression of MMP2 mRNA in verruvous carcinoma was significantly higher than that in squamous cell carcinoma.