Effects of long-term estrogen replacement treatment on the blood pressure and expression of IR and IRS-1 in myocardium / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 38-56, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-813479
ABSTRACT
OBJECTIVE@#To determine the effects of long-term estrogen replacement treatment on blood pressure and expressions of insulin receptor (IR) and insulin receptor substrate-1 ( IRS-1) in myocardium.@*METHODS@#Fifty female SD rats were randomly divided into 3 groups. And then sham ( n = 16), ovariectomy (OVX, n = 17), and estrogen replacement treatment group (OVX + E2, n = 17) were established. Systolic blood pressure of tail artery was determined by tail-cuff technique before the operation and on week 12 after the operation. The expressions of IR and IRS-1 were measured by RT-PCR in myocardium of SD rats.@*RESULTS@#Blood pressure [ (118.75+/-2.77) mmHg] in OVX was significantly higher than that in the sham [ ( 103.86+/-1.84) mmHg, P 0.05 ). The difference of IR expression has no statistical significance among the 3 groups.@*CONCLUSION@#Long-term estrogen replacement treatment might protect cardiovascular system through decreasing the blood pressure and inducing the expression of IRS-1 in myocardium. However, plasma estrogen level doesn't significantly influence the IR expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Phosphoproteins
/
Time Factors
/
Blood Pressure
/
Receptor, Insulin
/
Ovariectomy
/
Estrogen Replacement Therapy
/
Rats, Sprague-Dawley
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Estradiol
/
Insulin Receptor Substrate Proteins
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2005
Type:
Article
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