Effects of simvastatin on TGF-beta system of diabetic rat kidneys / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 593-596, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-813497
ABSTRACT
OBJECTIVE@#To investigate the effects and mechanism of renal benefit of simvastatin on diabetic rat kidneys.@*METHODS@#Twenty STZ-induced SD rats and 10 normal rats were assigned to diabetic rat (DM) group, simvastatin [ 4 mg/( kg x d) ] treatment (S) group and normal control (C) group. Immunohistochemistry, RT-PCR and western-blot were employed to examine the changes of the mRNA and protein expression of TGF-beta1 and Tbeta II R in the kidneys of the rats.@*RESULTS@#Compared with the normal control group, both the mRNA and protein expression of TGF-beta1 and Tbeta II R in the diabetic rat group and treatment group were significantly increased (P < 0.05). Compared with the diabetic rat group, simvastatin could markedly decrease the mRNA and protein expression of TGF-beta1 and Tbeta II R (P < 0.05).@*CONCLUSION@#Simvastatim may play a protective role in the diabetic kidneys by down-regulating TGF-beta1 and Tbeta II R and inhibiting the TGF-beta signal pathway.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
RNA, Messenger
/
Random Allocation
/
Down-Regulation
/
Transforming Growth Factor beta
/
Rats, Sprague-Dawley
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Receptors, Transforming Growth Factor beta
/
Simvastatin
/
Diabetes Mellitus, Experimental
/
Diabetic Nephropathies
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2005
Type:
Article
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