Effect of vasoactive intestinal peptide and epidermal growth factor on the adhesion of eosinophils to bronchial epithelial cells

Xiang LI; Xiu-mei XING; Jian-song ZHANG; Yu-rong TAN

Effect of vasoactive intestinal peptide and epidermal growth factor on the adhesion of eosinophils to bronchial epithelial cells / 中南大学学报(医学版)

Xiang LI; Xiu-mei XING; Jian-song ZHANG; Yu-rong TAN.

Journal of Central South University(Medical Sciences) ; (12): 772-781, 2006.

Article in Chinese | WPRIM | ID: wpr-813601

ABSTRACT

ABSTRACT

OBJECTIVE@#To investigate the effect of intrapulmonary regulatory peptides on adhesion of eosinophils (EOS) to bronchial epithelial cells (BECs).@*METHODS@#Two regulatory peptides, namely vasoactive intestinal peptide (VIP) and epidermal growth factor (EGF) were investigated. VIP and EGF were observed on the secretion of ILs and expression of intercellular adhesion molecule-1 (ICAM-1).@*RESULTS@#VIP and EGF could decrease ILs secretion and ICAM-1 expression.@*CONCLUSION@#VIP and EGF inhibited the adhesion of EOS to BEC in the inflammatory process to lighten the airway inflammation.

Subject(s)

Animals; Female; Male; Rabbits; Bronchi; Cell Biology; Cell Adhesion; Cells, Cultured; Eosinophils; Cell Biology; Epidermal Growth Factor; Physiology; Epithelial Cells; Cell Biology; Intercellular Adhesion Molecule-1; Interleukin-5; Vasoactive Intestinal Peptide; Physiology

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Bronchi / Vasoactive Intestinal Peptide / Cell Adhesion / Cells, Cultured / Interleukin-5 / Intercellular Adhesion Molecule-1 / Cell Biology / Eosinophils / Epidermal Growth Factor Limits: Animals Language: Chinese Journal: Journal of Central South University(Medical Sciences) Year: 2006 Type: Article

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