Effect of cortisol on ischemic preconditioning in rabbit hearts / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 667-670, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-813624
ABSTRACT
OBJECTIVE@#To determine the effects of reacting cortisol on ischemic preconditioning (IPC).@*METHODS@#Thirty rabbits were randomized into ischemic preconditioning (IPC) group, etomidate (Etom) group, ischemic/reperfusion (IR) group, methylprednisolone (MP) group and a control group. The ratios of infarction size versus risk area (Infarct/Risk) were calculated. The elevations of serum CK activity and cTnI concentrations as well as serum cortisol concentrations were measured.@*RESULTS@#The ratios of Infarct/Risk were 5.9%+/-2.8% for IPC, 11.3%+/-3.6% for Etom, 26.8%+/-4.5% for IR and 18.2%+/-3.7% for MP. The elevations of serum CK activity (U/L) were 255+/-89 for IPC, 314+/-160 for Etom, 855+/-371 for IR and 768+/-404 for MP, the elevations of serum cTnI concentrations (microg/L) were 3.6+/-0.6 for IPC, 5.9+/-2.0 for Etom, 8.1+/-3.6 for IR and 6.1+/-2.3 for MP. Those indicators among groups are all significantly different (P<0.01). Cortisol reacting was markedly diminished in Etom group.@*CONCLUSION@#A blunted cortisol reaction can markedly undermine the benefit of ischemic preconditioning, methylprednisolone show a certain myocardial protection. Cortisol may play an important role in the IPC process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Methylprednisolone
/
Myocardial Reperfusion Injury
/
Random Allocation
/
Ischemic Preconditioning, Myocardial
/
Therapeutic Uses
/
Creatine Kinase, MB Form
/
Etomidate
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2006
Type:
Article
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