MICA*008/A5.1 allele and HCMV infection in kidney transplanted donees of Hunan Han nationality / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 479-482, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-813667
ABSTRACT
OBJECTIVE@#To investigate the relationship between MICA*008/A5.1 allele and human cytomegalovirus (HCMV) infection in kidney transplanted donees of Hunan Han nationality.@*METHODS@#The MICA*008/A5.1 allele based on 91 kidney transplanted donees and 81 unrelated normal individuals of Han nationality in Hunan Province were analyzed by PCR/SSP assay. At the same time, anti-HCMV antibody IgM was detected in the serum by ELISA method.@*RESULTS@#The positive rate of MICA*008/A5.1 allele was significantly higher in the control group (56.79%) than that in the kidney transplanted donee group (34.07%) (P <0.05). The infection rate of HCMV in those individuals whose genotype was MICA*008/A5.1 (-) was significantly higher than that in the MICA*008/A5.1(+).@*CONCLUSION@#The individual whose genotype is MICA*008/A5.1 (+) is not liable to HCMV infection, but the individual whose genotype is MICA*008/A5.1 (-) is liable to HCMV infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Immunoglobulin M
/
Histocompatibility Antigens Class I
/
China
/
Kidney Transplantation
/
Cytomegalovirus Infections
/
Cytomegalovirus
/
Alleles
/
Genetics
/
Genotype
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2006
Type:
Article
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