Estrogen receptor gene polymorphisms and HBV-induced liver cirrhosis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 379-382, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-813693
ABSTRACT
OBJECTIVE@#To investigate the relationship between estrogen receptor (ER) gene polymorphisms and HBV-induced cirrhosis.@*METHODS@#Xba I and Pvu II polymorphisms of ER gene were analyzed in 98 patients with HBV-induced cirrhosis, 72 patients with chronic hepatitis B, and 84 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.@*RESULTS@#The frequencies of Pp genotype and P allele of ER gene in patients with HBV-induced cirrhosis were higher than those in patients with chronic hepatitis B and controls, while the frequencies of pp genotype and p allele of ER gene in patients with HBV-induced cirrhosis were lower than those in patients with chronic hepatitis B and controls (P 0.05).@*CONCLUSION@#Pp genotype and P allele might be the susceptibility gene for HBV-induced cirrhosis while pp genotype and p allele might be the protective gene.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Polymorphism, Restriction Fragment Length
/
Receptors, Estrogen
/
Polymerase Chain Reaction
/
Hepatitis B, Chronic
/
Alleles
/
Genetics
/
Genotype
/
Liver Cirrhosis
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2006
Type:
Article
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