Protective effect of lidocaine on injury alveolar Type II cells induced by LPS in adult rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 241-244, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-813725
ABSTRACT
OBJECTIVE@#To investigate the effect of lidocaine on LPS induced apoptosis of cultured adult rat alveolar Type II (AT-II) cells.@*METHODS@#Cultured cells were exposed to LPS and lidocaine for 24 hours. Apoptosis and necrosis rates of cells were detected by flow cytometry and electron microscope. The activity of lactic dehydrogenase (LDH) was analyzed by using LDH kits.@*RESULTS@#LPS induced the AT-II cell injuries by increasing not only the necrosis and apoptosis rates but also the LDH release of cultured AT-II in vitro. Lidocaine decreased the necrosis and apoptosis rates of AT-II cells.@*CONCLUSION@#Lidocaine can directly inhibit the apoptosis and necrosis induced by LPS in cultured AT-II cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Pulmonary Alveoli
/
Cells, Cultured
/
Lipopolysaccharides
/
Rats, Sprague-Dawley
/
Apoptosis
/
Protective Agents
/
Lactate Dehydrogenases
/
Epithelial Cells
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2006
Type:
Article
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