Progression of lipopolysaccharide signal pathway / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 141-145, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-813746
ABSTRACT
Lipopolysaccharide (LPS) is the major constituents of the outer membrane of Gram-negative bacteria. LPS recognition and signal transmission are key events in the host defense reaction towards Gram-negative bacteria and are associated with many disorders. Multiple signaling pathways are involved in the response to LPS. With the help of LPS-binding protein and CD14, TLR4 binds with LPS, then recruits myeloid differentiation factor 88 and IL-1 receptor-associated kinase, and further phosphorylates and activates TNF receptor associated factor 6 (TRAF6). The activated TRAF6 leads to the activation of transcription factor NF-kappaB and MAP kinase's pathways that involves in LPS-induced cellular responses and the production of proinflammatory cytokines such as TNF-alpha, IL-6 and IL8.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Acute-Phase Proteins
/
Membrane Glycoproteins
/
Signal Transduction
/
Carrier Proteins
/
Chemistry
/
Lipopolysaccharides
/
NF-kappa B
/
Lipopolysaccharide Receptors
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2006
Type:
Article
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