Expression of cardiotrophin-1 and effects of irbesartan in adriamycin induced cardiomyopathy in rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 574-578, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-813838
ABSTRACT
OBJECTIVE@#To investigate cardiotrophin-1(CT-1) expression in the ventricle and the effects of angiotensin II type I receptor antagonist (AT(1)RA) irbesartan on the ventricular remodeling in adriamycin myocardiopathy.@*METHODS@#Thirty male SD rats were randomized into 2 groups a control group (n=10) and a model group (n=20). The model group was administered adriamycin and 18 rats survived. And theses rats were randomized again into 2 groups. One was treated with irbesartan [50 mg/(kg x d), with stomach-tube], and the other received equal saline, so did the control group. After 12 weeks, the protein level of CT-1 was detected by immunohistochemistry.@*RESULTS@#Ventricular CT-1 in the model control group and the treatment group was higher than that in the control group and the correlation analysis showed that ventricular CT-1 of the model control group was positively correlated with the left ventricular weight index, and CT-1 of the treatment group was lower than that of the model control group.@*CONCLUSION@#CT-1 was assumed to take part in the ventricular remodeling. The mechanism of irbesartan on the ventricular remodeling may be related to the downregulation of CT-1 expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Tetrazoles
/
Biphenyl Compounds
/
Doxorubicin
/
Cytokines
/
Rats, Sprague-Dawley
/
Ventricular Remodeling
/
Myocytes, Cardiac
/
Angiotensin II Type 1 Receptor Blockers
/
Irbesartan
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2007
Type:
Article
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