Genomic instability in nasopharyngeal carcinoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 417-421, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-813869
ABSTRACT
OBJECTIVE@#To evaluate the effect of genomic instability on prognostics in nasopharyngeal carcinoma.@*METHODS@#Genomic instability was assessed by inter-simple sequence repeats polymerase chain reaction (inter-SSR PCR) in 38 patients with nasopharyngeal carcinoma. Characterization and verification of band alterations shared in different tumors were carried out by sequencing and nest PCR.@*RESULTS@#Thirty-one (81.6%) of the 38 patients showed genomic altercations, and genomic instability index ranged 0 to 16.2 percent. A gain-based genomic damage shared in 6 tumors was identified on chromosome 6q27. Genomic alteration was significantly more in patients less than 5-year survival than those with more than 5-year survival (P<0.05).@*CONCLUSION@#Genomic instability can be an early event marker in carcinogenesis of nasopharyngeal carcinoma. Aggravation of genomic alterations is a poor prognosis for cancer recovery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Chromosomes, Human, Pair 3
/
Chromosomes, Human, Pair 6
/
DNA Mutational Analysis
/
Molecular Sequence Data
/
Base Sequence
/
Survival Analysis
/
Nasopharyngeal Neoplasms
/
Polymerase Chain Reaction
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2007
Type:
Article
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