High myopia and retinal ultrastructure of albino guinea-pigs / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 282-287, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-813893
ABSTRACT
OBJECTIVE@#To explore the relationship between melanin synthesis and the congenital high myopia of albino guinea-pigs.@*METHODS@#Twelve albino guinea-pigs and 12 pigmented guinea-pigs of 220~250 grams (aged 5~6 weeks) were chosen at random. The eyes were examined with retinoscopy, A-scan ultrasonography and vernier caliper. The retinal structures were examined with light and electronic microscope.@*RESULTS@#The diopter was -19.17 D in albino guinea-pigs and +0.63 D in pigmented guinea-pigs on average. Compared with the pigmented guinea-pigs, the axial dimensions of the albino guinea-pigs were elongated. There was significant difference between the albino guinea-pigs and the pigmented guinea-pigs. The retinal thickness, pigment granules and membrane disc of the outer segment of the visual cells decreased in the albino guinea-pigs, and the membrane disc space became narrow. The normal retinal thickness, plenty of pigment granules , membrane disc and wide membrane disc space could be observed in the pigmented guinea-pigs.@*CONCLUSION@#Albino guinea-pigs have high myopia, and pigmented guinea pigs have light hyperopia. There are structural differences in the retina between albino guinea-pigs and pigmented guinea-pigs. The abnormity of albino guinea-pigs provides optical foundation for its high myopia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Retina
/
Skin Pigmentation
/
Microscopy, Electron, Scanning
/
Random Allocation
/
Albinism
/
Guinea Pigs
/
Melanins
/
Metabolism
/
Myopia
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2007
Type:
Article
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