Experimental study of acute lung injury induced by glutamate in vivo / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 78-81, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-813933
ABSTRACT
OBJECTIVE@#To investigate the possible injury induced by glutamate in the lung.@*METHODS@#The lung wet weight/body weight (LW/BW), lung wet/dry weight (W/D), the content of cells and the total protein (TP) in bronchoalveolar lavage fluid (BALF) were determined together with the micromorphology observation.@*RESULTS@#(1) The LW/BW, W/D, the content of white blood cells, red blood cells and TP in BALF increased in a dose dependent manner 2 hours after the administration of the glutamate (0.50 - 0.75 g/kg). (2) Examination of histological sections showed the presence of lung inflammation charactered by neutrophils recruitment 2 hours after the glutamate administration. (3) The increase of W/D caused by glutamate (0.50 g/kg) was nearly abolished by pre-treatment with MK801 (a specific blocker of NMDA receptor, 0.1 mg/kg) for 30 minutes (P<0.05).@*CONCLUSION@#Glutamate can cause the acute lung injury through the activation of NMDA receptor in vivo.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Bronchoalveolar Lavage Fluid
/
Acute Disease
/
Dizocilpine Maleate
/
Receptors, N-Methyl-D-Aspartate
/
Glutamic Acid
/
Cell Biology
/
Erythrocyte Count
/
Toxicity
/
Leukocyte Count
Limits:
Animals
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2007
Type:
Article
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