Protective effect of abnormal savda munzip on radiation-induced damage in mice / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To investigate the protective effect of abnormal savda munzip on the radiation-induced damaged in mice.@*METHODS@#The mice were randomly divided into 2 groups a control group and a drug group; the latter was again divided into a low dosage group (6.25%), a moderate dosage group (12.5%) and a high dosage group (25%) according to the drug concentration. All mice were given general radiation emitted by 6 Gy MV-X liner accelerator once, which resulted in the acute radiation damage. The different administrations of abnormal savda munzip were fed to the mice in the drug group orally for 7 days consecutively before and after the radiation. On the day of the last administration, 10 mice were sacrificed, and white blood cells, red cells and blood plates of the peripheral blood, spleen index, and spleen SOD were detected; while the 20 remaining mice were fed continually till 30 days, and the 30 day survival ratio of the mice was calculate.@*RESULTS@#(1) Although the mice weight in the drug groups was higher than that in the control group, no significant difference existed (P>0.05). Spleen index in the control group was higher than that in the drug group. (2) Spleen SOD was significantly increased by the drugs compared with that of the control group (P0.05). (4) Compared with the control group, a marked improvement of 30 day survival rate in all drug groups was observed (P<0.0001). Both the concentration and the survival rate were increased (P<0.01). (5) The SOD level and leukocyte counts in the irradiated mice were positively related to the survival ratio (r=0.612, P<0.005; r=0.32, P<0.05, respectively).@*CONCLUSION@#The abnormal savda munzip has significant protective function on the mice irradiated by 7 Gy MV-X liner accelerator.