Changes of plasma CD40L and PAPP-A in patients with acute coronary syndrome after the PCI operation / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 1098-1101, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-813942
ABSTRACT
OBJECTIVE@#To observe the changes and significance of plasma CD40L and pregnancy-associated plasma protein-A (PAPP-A) in acute coronary syndrome (ACS) patients after percutaneous coronary intervention (PCI) operation.@*METHODS@#According to the occurrence of primary heart events or restenosis 6 months after the PCI, 68 patients were divided into the ACS group and the stable angina pectoris (SAP) group. Plasma CD40L and PAPP-A after the PCI operation were measured and compared. Thirty-six patients underwent repeated angiography after the PCI. Their baseline and follow up angiograms were compared by quantitative coronary angiography to assess the incidence of restenosis.@*RESULTS@#CD40L and PAPP-A after the PCI operation were higher in the ACS group than that in the SAP group.The group having primary heart events within 6 months had higher level of PAPP-A after the PCI. The group having restenosis 6 months had higher level of PAPP-A after the PCI. The change of later loss index of coronary artery lumen diameter was correlated with PAPP-A level after the PCI.@*CONCLUSION@#CD40L and PAPP-A were higher in the ACS group, indicating the possible mechanism by which CD40L facilitates the plaque rupture via up-regulating the PAPP-A expression.Plasma PAPP-A level after the PCI possibly for cases the occurrence of primary heart events or restenosis within 6 months.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Period
/
Pregnancy-Associated Plasma Protein-A
/
Therapeutics
/
Blood
/
CD40 Ligand
/
Acute Coronary Syndrome
/
Angina, Stable
/
Percutaneous Coronary Intervention
/
Metabolism
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2007
Type:
Article
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