Clinical efficacy of irbesartan and amiodarone in elderly patients with paroxysmal atrial fibrillation / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 871-874, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-813984
ABSTRACT
OBJECTIVE@#To investigate the effect of combination of irbesartan and amiodarone in elderly patients with paroxysmal atrial fibrillation.@*METHODS@#Ninety-one patients with paroxysmal atrial fibrillation were randomly divided into 2 groups Group I (amiodarone group, n=45) and Group II (amiodarone plus Irbesartan group, n=46).After 18 month follow-up, the maintenance rate of sinus rhythm was measured in the 3rd, 6th, 9th, 12th, and 18th months, and the left atrial diameter (LAD) was measured before the treatment and 6th, 12th, and 18th months after the treatment.@*RESULTS@#There was no difference in the maintenance rate of sinus rhythm between Group I and Group II in the 3rd month. The maintenance rate of sinus rhythm in Group I was 72.1%, 65.1%, 60.5%, and 55.8% in the 6th, 9th, 12th, and 18th months, and the rate in the Group II was 88.6%, 86.4%, 81.8%, and 79.5%. They both had significant difference (P<0.05). At 12 months after the treatment, LAD in Group I was significantly larger than that of Group II (P<0.05).@*CONCLUSION@#The combination of irbesartan and amiodarone is more effective than amiodarone alone for sinus rhythm maintenance, and may restrain the enlargement of the left atrium.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Atrial Fibrillation
/
Tetrazoles
/
Biphenyl Compounds
/
Treatment Outcome
/
Therapeutic Uses
/
Drug Therapy
/
Drug Therapy, Combination
/
Irbesartan
/
Amiodarone
/
Anti-Arrhythmia Agents
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Central South University(Medical Sciences)
Year:
2008
Type:
Article
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